ARG30272
Phospho p38 MAPK Antibody Duo (Total, pThr180 / Tyr182)
Publication13
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG55258 | anti-p38 MAPK antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, WB | 50 μl |
| ARG51850 | anti-p38 MAPK phospho (Thr180 / Tyr182) antibody | Rabbit pAb | Hu, Ms, Rat | WB | 50 μl |
Overview
| Product Description | p38 MAP kinase (MAPK), also called RK or CSBP, is the mammalian orthologue of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress. Four isoforms of p38 MAPK, p38α, β, γ (also known as Erk6 or SAPK3), and δ (also known as SAPK4) have been identified. p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light, and growth factors. MKK3, MKK6, and SEK activate p38 MAPK by phosphorylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF-2 , Max, and MEF2. Rouse, J. et al. (1994) Cell 78, 1027-37. Han, J. et al. (1994) Science 265, 808-11. Lee, J.C. et al. (1994) Nature 372, 739-46. Freshney, N.W. et al. (1994) Cell 78, 1039-49. Raingeaud, J. et al. (1995) J Biol Chem 270, 7420-6. Zervos, A.S. et al. (1995) Proc Natl Acad Sci U S A 92, 10531-4. Yang, S.H. et al. (1999) Mol Cell Biol 19, 4028-38 |
|---|---|
| Target Name | p38 MAPK |
| Alternate Names | Phospho p38 MAPK antibody; Phospho Mitogen-activated protein kinase 14 antibody; p38 MAPK phospho (Thr180 / Tyr182) antibody; p38 MAPK antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Images (5) Click the Picture to Zoom In
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ARG51850 anti-P38 MAPK phospho (Thr180/Tyr182) antibody WB image
Western Blot: extracts from HeLa cells untreated or treated with TNFa+CA stained with anti-P38 MAPK (phospho Thr180/Tyr182) antibody ARG51850.
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ARG55258 anti-p38 MAPK antibody ICC/IF image
Immunofluorescence: A549 cell stained with ARG55258 anti-p38 MAPK antibody. Blue: DAPI for nuclear staining.
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ARG55258 anti-p38 / MAPK14 antibody ICC/IF image
Immunofluorescence: A549 cell stained with ARG55258 anti-p38 / MAPK14 antibody. Blue: DAPI for nuclear staining.
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ARG55258 anti-p38 MAPK antibody WB image
Western blot: 30 µg of HeLa, and Mouse liver lysate stained with ARG55258 anti-p38 MAPK antibody at 1:2000 dilution.
Specific References
HuMSC-EVs Protect Endothelial Cells Against Hypoxia/Reoxygenation Injury by Inhibiting the Pannexin 1/p38-MAPK Pathway
ARG51850: WB / Human
Shionone relieves oxygen-glucose deprivation/reoxygenation induced SH-SY5Y cells injury by inhibiting the p38 MAPK/NF-κB pathway
ARG51850: WB / Human
Structural characterization and immunomodulatory activity of an acidic polysaccharide from walnut green husk
ARG51850: WB / Mouse
DHPA Protects SH-SY5Y Cells from Oxidative Stress-Induced Apoptosis via Mitochondria Apoptosis and the Keap1/Nrf2/HO-1 Signaling Pathway
ARG51850: WB / Human
Cobalt protoporphyrin promotes human keratinocyte migration under hyperglycemic conditions
ARG51850, ARG55258: WB / Human
Angiotensin II Induces Cardiac Edema and Hypertrophic Remodeling through Lymphatic-Dependent Mechanisms
ARG51850: WB / Mouse ARG55258: WB / Mouse
Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats.
ARG51850: WB / Rat
Inhibition of inflammatory response by α-lipoic acid in autoimmune thyroiditis mice.
ARG55258: WB / Mouse
Shikonin Induced Program Cell Death through Generation of Reactive Oxygen Species in Renal Cancer Cells
ARG51850: WB / Human
Discoidin Domain Receptor 1 Regulates Runx2 during Osteogenesis of Osteoblasts and Promotes Bone Ossification via Phosphorylation of p38.
ARG55258: WB / Mouse
Polyphenols from Toona sinensiss Seeds Alleviate Neuroinflammation Induced by 6-Hydroxydopamine Through Suppressing p38 MAPK Signaling Pathway in a Rat Model of Parkinson's Disease.
ARG55258: WB, ICC/IF / Rat
The Different Effects of IFN- β and IFN- γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells
ARG51850: WB / Human
Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways.
ARG55258: WB / Mouse
