ARG30052
Phospho mTOR Antibody Duo (Total, pS2448)
Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody
Publication3
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG54675 | anti-mTOR antibody | Rabbit pAb | Hu, Ms | ELISA, ICC/IF, WB | 25 μg |
| ARG51712 | anti-mTOR phospho (Ser2448) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
Overview
| Product Description | The mammalian target of rapamycin (mTOR) regulates cell growth with the growth factor and nutrient status of the cell. mTOR is a direct substrate for the AKT kinase that phosphorylates mTOR at Ser-2448. Later it was found that the phosphorylation of mTOR at Ser-2448 also requires autophosphorylation at Ser-2481. mTOR phospho duo allows scientists to study the function of mTOR in the cell proliferation and homeostasis abnormality in tumor cells. The control of mTOR pSer-2448 phosphorylation by insulin might give more insight into the potential of mTOR as a target for cancer therapy. |
|---|---|
| Target Name | mTOR |
| Alternate Names | Phospho mTOR antibody; Phospho mechanistic target of rapamycin antibody; mTOR phospho (Ser2448) antibody; mTOR antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho mechanistic target of rapamycin (mTOR) Antibody Duo (Total, pS2448) |
|---|---|
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody |
Images (7) Click the Picture to Zoom In
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ARG51712 anti-mTOR phospho (Ser2448) antibody WB image
Western Blot: extracts from HeLa cells, treatedwith IFNa or calf intestinal phosphatase (CIP), stained with anti-mTOR (phospho Ser2448) antibody ARG51712.
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ARG51712 anti-mTOR phospho (Ser2448) antibody WB image
Western Blot: extracts from 293 cells untreatedor treated with PMA stained with anti-mTOR (phospho Ser2448) antibody ARG51712.
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ARG51712 anti-mTOR phospho (Ser2448) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-mTOR (phospho Ser2448) antibody ARG51712 (left) or the same antibody preincubated with blocking peptide (right).
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ARG51712 anti-mTOR phospho (Ser2448) antibody ICC/IF image
Immunofluorescence: methanol-fixed MCF cells stained with anti-mTOR (phospho Ser2448) antibody ARG51712.
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ARG51712 anti-mTOR phospho (Ser2448) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinomatissue stained with ARG51712 anti-mTOR (phospho Ser2448) antibody.
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ARG54675 anti-mTOR antibody ICC/IF image
Immunocytochemistry: L1210 cells stained with ARG54675 anti-mTOR antibody at 2 μg/ml.
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ARG54675 anti-mTOR antibody WB image
Western blot: L1210 cell lysate stained with ARG54675 anti-mTOR antibody at (A) 1 and (B) 2 μg/ml.
Specific References
Ramulus Mori (Sangzhi) Alkaloids (SZ-A) Ameliorate Myocardial Injury in Type 2 Diabetic Rats by Regulating Autophagy
ARG51712: WB / Rat
Astilbin ameliorates oxidative stress and apoptosis in D-galactose-induced senescence by regulating the PI3K/Akt/m-TOR signaling pathway in the brains of mice
ARG51712: WB / Mouse
1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.
ARG51712: WB / Human
