ARG30219
Phospho PDK1 Antibody Duo (Total, pS241)
Signaling Transduction antibody
Publication1
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51509 | anti-PDPK1 phospho (Ser241) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG51005 | anti-PDPK1 antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
Overview
| Product Description | 3-Phosphoinositide dependent protein kinase -1 (PDK-1) is responsible for regulating activity of AKT by phosphorylating specific threonine and serine residues within its activation loop. PDK-1 itself can be phosphorylated at Ser-25, Ser-241. Ser-393, Ser-396 and Ser-410 by the stimulation of Insulin-like growth factor. Phosphorylation at Ser241 residue is essential for the enzymatic activity of PDK-1. Gagliardi et al. 2012. Neoplasia 14(8):719-31 Casamayor et al. 1999. Biochem J 342: 287-92 |
|---|---|
| Target Name | PDK1 |
| Alternate Names | Phospho PDK1 antibody; PDPK1 antibody; PDPK1 phospho (Ser241) antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho PDK1 Antibody Duo (Total, pS241) |
|---|---|
| Research Area | Signaling Transduction antibody |
Images (6) Click the Picture to Zoom In
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ARG51005 anti-PDK1 antibody WB image
Western Blot: extracts from MCF, 293 and PC12 cells stained with anti-PDK1 antibody ARG51005.
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ARG51005 anti-PDK1 antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-PDK1 antibody ARG51005 (left) or the same antibody preincubated with blocking peptide (right).
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ARG51005 anti-PDK1 antibody ICC/IF image
Immunofluorescence: methanol-fixed MCF7 cells stained with anti-PDK1 antibody ARG51005.
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ARG51509 anti-PDK1 phospho (Ser241) antibody WB image
Western Blot: extracts from 293 and PC12 cells untreated or treated with EGF stained with anti-PDK1 (phospho Ser241) antibody ARG51509.
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ARG51509 anti-PDK1 phospho (Ser241) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-PDK1 (phospho Ser241) antibody ARG51509 (left) or the same antibody preincubated with blocking peptide (right).
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ARG51509 anti-PDK1 phospho (Ser241) antibody ICC/IF image
Immunofluorescence: methanol-fixed HeLa cells stained with anti-PDK1 (phospho Ser241) antibody ARG51509.
Specific References
Combination of N, N'-dicyclohexyl-N-arachidonic acylurea and tacrolimus prolongs cardiac allograft survival in mice.
ARG51509: WB / Mouse
