Focal Adhesion Kinase (FAK), also known as PTK2 protein tyrosine kinase 2 (PTK2), is a non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis.

Increased levels of FAK and Src proteins found in tumors and the importance of the FAK-Src signaling complex to tumor cell behavior, in addition, phosphorylation of FAK Tyr925 is a Src-dependent phosphorylation. Therefore, suggests that phosphorylation of Tyr925 on FAK may provide a useful indicator of increased signaling through the Src-FAK signaling complex in tumors. On the other hand, a RET-FAK transactivation mechanism consisting of direct phosphorylation of FAK Tyr-576/577 by RET but not Tyr925 and a reciprocal phosphorylation of RET by FAK.

To study the correction of FAK and your protein of interest, ARG30025 FAK phospho Duos provides antibodies to detect the phosphorylated-FAK at Tyr576/577 or Tyr925 for the user in FAK study.