ARG30024
Phospho CREB (pS133) / Phospho beta Catenin (pS37) Antibody Duo
Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Gene Regulation antibody; Immune System antibody; Neuroscience antibody; Signaling Transduction antibody
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51556 | anti-CREB phospho (Ser133) antibody | Rabbit pAb | Hu, Ms, Rat | IHC-P, WB | 50 μl |
| ARG51710 | anti-beta Catenin phospho (Ser37) antibody | Rabbit pAb | Hu, Ms, Rat | IHC-P, WB | 50 μl |
Overview
| Product Description | Constitutively active GSK-3 acts to destabilize beta catenin through phosphorylation (Ser37), thus, functioning as a tumor suppressor to limit proliferation. In contrast, GSK-3 promotes expansion of leukemic cells transformed by HOX overexpression through phosphorylation of CREB (Ser133) and subsequent formation of a transcriptional coactivator complex. (Cancer Cell 17, June 15, 2010) |
|---|---|
| Target Name | CREB / beta Catenin |
| Alternate Names | Phospho CREB (pS133) / Phospho beta Catenin (pS37) antibody; Phospho cAMP responsive element binding protein (pS133) / Phospho beta Catenin (pS37) antibody; CREB phospho (Ser133) antibody; beta Catenin phospho (Ser37) antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho cAMP responsive element binding protein (CREB) (pS133) / Phospho beta Catenin (pS37) Antibody Duo |
|---|---|
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Gene Regulation antibody; Immune System antibody; Neuroscience antibody; Signaling Transduction antibody |
Images (4) Click the Picture to Zoom In
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ARG51556 anti-CREB phospho (Ser133) antibody WB image
Western Blot: extracts from HeLa cells untreated or treated with UV stained with anti-CREB (phospho Ser133) antibody ARG51556.
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ARG51710 anti-beta Catenin phospho (Ser37) antibody WB image
Western Blot: extracts from HT29 cells stained with anti-beta Catenin (phospho Ser37) antibody ARG51710 and the same antibody preincubated with blocking peptide .
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ARG51556 anti-CREB phospho (Ser133) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-CREB (phospho Ser133) antibody ARG51556 (left) or the same antibody preincubated with blocking peptide (right).
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ARG51710 anti-beta Catenin phospho (Ser37) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-beta Catenin (phospho Ser37) antibody ARG51710 (left) or the same antibody preincubated with blocking peptide (right).
