ARG83268
Mouse/Rat DCC ELISA Kit
Mouse/Rat DCC ELISA Kit for ELISA and Mouse,Rat
Overview
| Product Description | ARG83268 Mouse/Rat DCC ELISA Kit is an Enzyme Immunoassay kit for the quantification of Mouse/Rat DCC in Serum, Plasma and Cell culture supernatants. |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | ELISA |
| Specificity | There is no detectable cross-reactivity with other relevant proteins. |
| Target Name | DCC |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 13 pg/ml |
| Detection Range | 23.4 pg/ml - 1,500 pg/ml |
| Sample Type | Serum, Plasma and Cell culture supernatants |
| Precision | Intra-Assay CV: 6.0% Inter-Assay CV: 5.1% |
| Alternate Names | Tumor suppressor protein DCC; Immunoglobulin superfamily DCC subclass member 1; CRC18; NTN1R1; MRMV1; Colorectal cancer suppressor; IGDCC1; CRCR1; Netrin receptor DCC |
Application Instructions
| Assay Time | ~ 5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DCC |
| Gene Full Name | DCC netrin 1 receptor |
| Background | This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009] |
| Function | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [UniProt] |
| PTM | Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG83268 Mouse / Rat DCC ELISA Kit standard curve image
ARG83268 Mouse / Rat DCC ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83268 Mouse / Rat DCC ELISA Kit User manual |
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