ARG70499
Mouse EpCAM recombinant protein (His-tagged)
Mouse EpCAM recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Mouse EpCAM recombinant protein. |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | EpCAM |
| Species | Mouse |
| A.A. Sequence | Met1-Thr266 |
| Expression System | CHO |
| Protein Full Name | Epithelial cell adhesion molecule |
| Alternate Names | EPCAM; Epithelial Cell Adhesion Molecule; TROP1; KSA; Tumor-Associated Calcium Signal Transducer 1; GA733-2; Ber-Ep4; TACSTD1; Ep-CAM; MOC-31; BerEp4; EGP40; EGP-2; KS1/4; MIC18; MK-1; M4S1; ESA; Major Gastrointestinal Tumor-Associated Protein GA733-2; Trophoblast Cell Surface Antigen 1; Adenocarcinoma-Associated Antigen; Cell Surface Glycoprotein Trop-1; Epithelial Glycoprotein 314; TACST-1; HEA125; 323/A3; CO-17A; EGP314; EGP34; CD326; MOC31; 17-1A; Ly74; MH99; Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein); Antigen Identified By Monoclonal Antibody AUA1; Human Epithelial Glycoprotein-2; Epithelial Cell Surface Antigen; Epithelial Glycoprotein; KS 1/4 Antigen; CD326 Antigen; HEGP314; HNPCC8; LYNCH8; DIAR5; M1S2; EGP |
Properties
| Form | Powder |
|---|---|
| Purification | >95% (by SDS-PAGE) |
| Purification Note | Endotoxin level is <0.1 EU/µg of the protein, as determined by the LAL test. |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not <200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | EPCAM |
|---|---|
| Gene Full Name | Epithelial Cell Adhesion Molecule |
| Background | This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008] |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.[Uniprot] |
