ARG83219
Mouse CD271 / NGFR p75 ELISA Kit
Mouse CD271 / NGFR p75 ELISA Kit for ELISA and Mouse
Developmental Biology antibody; Neuroscience antibody
Overview
| Product Description | ARG83219 Mouse CD271 / NGFR p75 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Mouse CD271 / NGFR p75 in Serum, Cell lysates, Plasma and Cell culture supernatants. |
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| Tested Reactivity | Ms |
| Tested Application | ELISA |
| Specificity | There is no detectable cross-reactivity with other relevant proteins. |
| Target Name | CD271 / NGFR p75 |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 15 pg/ml |
| Detection Range | 31.2 pg/ml - 2,000 pg/ml |
| Sample Type | Serum, Cell lysates, Plasma and Cell culture supernatants |
| Precision | Intra-Assay CV: 6.4% Inter-Assay CV: 7.6% |
| Alternate Names | Gp80-LNGFR; CD271; CD antigen CD271; p75 ICD; Tumor necrosis factor receptor superfamily member 16; p75NTR; NGF receptor; TNFRSF16; p75(NTR); Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor |
Application Instructions
| Assay Time | ~ 5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | NGFR |
|---|---|
| Gene Full Name | nerve growth factor receptor |
| Background | CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells. |
| Function | Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. [UniProt] |
| Research Area | Developmental Biology antibody; Neuroscience antibody |
| PTM | N- and O-glycosylated. O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. Phosphorylated on serine residues. |
Images (1) Click the Picture to Zoom In
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ARG83219 Mouse CD271 / NGFR p75 ELISA Kit standard curve image
ARG83219 Mouse CD271 / NGFR p75 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83219 Mouse CD271 / NGFR p75 ELISA Kit User manual |
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