ARG70489
Mouse CD16 recombinant protein (His-tagged)
Mouse CD16 recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Mouse CD16 recombinant protein. |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD16 |
| Species | Mouse |
| A.A. Sequence | Met1-Thr215 |
| Expression System | CHO |
| Protein Full Name | Fc gamma receptor III |
Properties
| Form | Powder |
|---|---|
| Purification | >95% (by SDS-PAGE) |
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | Fcgr3 |
|---|---|
| Gene Full Name | Fc gamma receptor III |
| Background | CD16, also known as Fc gamma receptor III (FcγRIII), is a transmembrane protein primarily found on the surface of natural killer (NK) cells, macrophages, and a subset of T cells. It plays a critical role in mediating antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis. CD16 binds to the Fc portion of immunoglobulin G (IgG) antibodies, facilitating the recognition and destruction of target cells or pathogens coated with antibodies. This interaction activates downstream signaling pathways, triggering cytotoxic responses. CD16's involvement in immune surveillance and host defense highlights its significance in immune regulation and therapeutic strategies targeting ADCC. |
