ARG70569
Mouse CD123 / IL3RA recombinant protein (His-tagged)
Mouse CD123 / IL3RA recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Mouse CD123 / IL3RA recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD123 / IL3RA |
| A.A. Sequence | Ser17 - Lys 331 |
| Expression System | CHO |
| Alternate Names | IL3RA; Interleukin 3 Receptor Subunit Alpha; CD123; Interleukin 3 Receptor, Alpha (Low Affinity); Interleukin-3 Receptor Subunit Alpha; IL-3 Receptor Subunit Alpha; IL-3R Subunit Alpha; CD123 Antigen; IL-3R-Alpha; IL3R; HIL-3Ra; IL3RAY; IL-3RA; IL3RX; IL3RY |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IL3RA |
|---|---|
| Gene Full Name | Interleukin 3 Receptor Subunit Alpha |
| Background | The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012] |
| Function | Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. [Uniprot] |
