ARG70503
Mouse ASGR1 / Asialoglycoprotein Receptor 1 recombinant protein (His-tagged)
Mouse ASGR1 / Asialoglycoprotein Receptor 1 recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Mouse ASGR1 / Asialoglycoprotein Receptor 1 recombinant protein. |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | ASGR1 / Asialoglycoprotein Receptor 1 |
| Species | Mouse |
| A.A. Sequence | Ser60-Asn284 |
| Expression System | CHO |
| Protein Full Name | Asialoglycoprotein receptor 1 |
| Alternate Names | ASGR1; Asialoglycoprotein Receptor 1 CLEC4H1; C-Type Lectin Domain Family 4 Member H1; Hepatic Lectin H1; HL-1; ASGP-R 1; ASGPR 1; ASGPR1; ASGPR |
Properties
| Form | Powder |
|---|---|
| Purification | >95% (by SDS-PAGE) |
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | ASGR1 |
|---|---|
| Gene Full Name | Asialoglycoprotein Receptor 1 |
| Background | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. [Uniprot] |
