ARG70523
Human Sclerostin recombinant protein (His-tagged)
Human Sclerostin recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Human Sclerostin recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | Sclerostin |
| A.A. Sequence | Gln24 - Tyr213 |
| Expression System | CHO |
| Alternate Names | SOST; Sclerostin; DAND6; VBCH; Sclerosteosis; SOST1; CDD |
Properties
| Form | Powder |
|---|---|
| Purity | > 85% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | SOST |
|---|---|
| Gene Full Name | Sclerostin |
| Background | Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008] |
| Function | Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. [Uniprot] |
