ARG83019
Human / Mouse BMP10 ELISA Kit
Human / Mouse BMP10 ELISA Kit for ELISA and Human,Mouse
Overview
| Product Description | ARG83019 Human / Mouse BMP10 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human / Mouse BMP10 in serum, plasma (heparin), ascites, urine and cell culture supernatants. |
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| Tested Reactivity | Hu, Ms |
| Tested Application | ELISA |
| Specificity | Not cross-reacts with: Human BMP5, BMP6, BMP9, BMPR1A. Mouse BMP5, BMP6, BMP9, BMPR1A. Rat BMP5, BMP6, BMP9, BMPR1A. |
| Target Name | BMP10 |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Protein Full Name | Bone morphogenetic protein 10 |
| Sensitivity | 7.8 pg/ml |
| Sample Type | Serum, plasma (heparin), ascites, urine and cell culture supernatants. |
| Standard Range | 15.6 - 1000 pg/ml |
| Sample Volume | 100 µl |
| Precision | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| Alternate Names | BMP10, Bone Morphogenetic Protein 10, BMP 10 |
Application Instructions
| Assay Time | ~ 4 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BMP10 |
| Gene Full Name | Bone Morphogenetic Protein 10 |
| Background | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016] |
| Function | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. [Uniprot] |
| Cellular Localization | Secreted. [UniProt] |
| Highlight | Related products: BMP antibodies; BMP ELISA Kits; BMP recombinant proteins; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| PTM | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG83019 Human/Mouse BMP10 ELISA Kit standard curve image
ARG83019 Human/Mouse BMP10 ELISA Kit results of standard run with optical density reading at 450 nm
| Title | Download Link |
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| ARG83019 Human/Mouse BMP10 ELISA Kit User manual |
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