ARG70506
Human IL6R alpha recombinant protein (His-tagged)
Human IL6R alpha recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Human IL6R recombinant protein. |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | IL6R alpha |
| Species | Human |
| A.A. Sequence | Met1-Ser232 |
| Expression System | CHO |
| Protein Full Name | Interleukin-6 receptor subunit alpha |
| Alternate Names | IL6R; Interleukin 6 Receptor; Gp80; Membrane Glycoprotein 80; IL-1Ra; CD126; IL-6R; IL6RA; Interleukin-6 Receptor Subunit Alpha; IL-6 Receptor Subunit Alpha; CD126 Antigen; IL-6RA; Interleukin 6 Receptor Subunit Alpha; IL-6R Subunit Alpha; IL-6R-Alpha; IL-6R-1; IL-6R 1; IL6QTL; HIES5; IL6RQ; IL6Q |
Properties
| Form | Powder |
|---|---|
| Purification | >95% (by SDS-PAGE) |
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IL6R |
|---|---|
| Gene Full Name | Interleukin 6 Receptor |
| Background | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020] |
| Function | The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. [Uniprot] |
