ARG70478
Human IL18 binding protein recombinant protein (His-tagged)
Human IL18 binding protein recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | HEK293 expressed, His-tagged Human IL18 binding protein recombinant protein. |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | IL18 binding protein |
| Species | Human |
| A.A. Sequence | Met1-Gly194 |
| Expression System | HEK293 |
| Protein Full Name | Interleukin-18-binding protein |
| Alternate Names | IL18BP; Interleukin 18 Binding Protein; IL18BPa; MC51L-53L-54L Homolog Gene Product; Interleukin-18-Binding Protein; Tadekinig-Alfa; IL-18BP; FVH |
Properties
| Form | Powder |
|---|---|
| Purification | >95% (by SDS-PAGE) |
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IL18BP |
|---|---|
| Gene Full Name | Interleukin 18 Binding Protein |
| Background | The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] |
| Function | Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. [Uniprot] |
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ARG70478 Human IL18 binding protein recombinant protein (His-tagged) SDS-PAGE image
SDS-PAGE analysis of ARG70478 Human IL18 binding protein recombinant protein (His-tagged).
