ARG82947
Human IL17A / IL17F Heterodimer ELISA Kit
Human IL17A / IL17F Heterodimer ELISA Kit for ELISA and Human
Overview
| Product Description | ARG82947 Human IL17A / IL17F Heterodimer ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human IL17A / IL17F Heterodimer in serum, plasma and cell culture supernatants. |
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| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Target Name | IL17A / IL17F Heterodimer |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 23.44 pg/ml |
| Sample Type | Serum, plasma and cell culture supernatants. |
| Standard Range | 46.88 - 3000 pg/ml |
| Sample Volume | 100 μl |
| Precision | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| Alternate Names | IL17A: IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8 IL17F: Interleukin-17F; IL-17F; CANDF6; ML-1; ML1; Cytokine ML-1 |
Application Instructions
| Assay Time | ~ 3.5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 4°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IL17A; IL17F |
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| Gene Full Name | interleukin 17A / interleukin 17F Heterodimer |
| Background | IL17A: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] IL17F: The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] |
| Function | IL17A: Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). [UniProt] IL17F: Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity). [UniProt] |
| Cellular Localization | IL17A and IL17F: Secreted. [UniProt] |
| Highlight | Related products: IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| PTM | IL17A: Found both in glycosylated and nonglycosylated forms. [UniProt] |
| Title | Download Link |
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| ARG82947 Human IL17A / IL17F Heterodimer ELISA Kit User manual |
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