ARG70383
Human HMGB2 recombinant protein (His-SUMO tagged, N-ter)
Human HMGB2 recombinant protein (His-SUMO tagged, N-ter) for SDS-PAGE
Overview
| Product Description | HEK293 expressed, His-SUMO tagged (N-ter) Human HMGB2 recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | HMGB2 |
| Species | Human |
| A.A. Sequence | Met1 - Pro187 |
| Expression System | HEK293 |
| Protein Full Name | High mobility group protein B2 |
| Alternate Names | HMGB2; High Mobility Group Box 2; HMG2; High-Mobility Group (Nonhistone Chromosomal) Protein 2; High Mobility Group Protein B2; High Mobility Group Protein 2; HMG-2; High-Mobility Group Box 2 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is <0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | >98% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not <200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | HMGB2 |
|---|---|
| Gene Full Name | High Mobility Group Box 2 |
| Background | This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. |
| Function | Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. |
| Cellular Localization | Chromosome, Cytoplasm, Nucleus, Secreted |
| PTM | Acetylation, Disulfide bond, Oxidation, Phosphoprotein |
Images (1) Click the Picture to Zoom In
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ARG70383 Human HMGB2 recombinant protein (His-SUMO tagged, N-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70383 Human HMGB2 recombinant protein (His-SUMO tagged, N-ter)
