ARG83298
Human HEXA ELISA Kit
Human HEXA ELISA Kit for ELISA and Human
Overview
| Product Description | ARG83298 Human HEXA ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human HEXA in Serum, Plasma and Cell culture supernatants. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | There is no detectable cross-reactivity with other relevant proteins. |
| Target Name | HEXA |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 75 pg/ml |
| Detection Range | 312 pg/ml - 20,000 pg/ml |
| Sample Type | Serum, Plasma and Cell culture supernatants |
| Precision | Intra-Assay CV: 4.6% Inter-Assay CV: 5.0% |
| Alternate Names | N-acetyl-beta-glucosaminidase subunit alpha; Beta-N-acetylhexosaminidase subunit alpha; EC 3.2.1.52; TSD; Beta-hexosaminidase subunit alpha; Hexosaminidase subunit A |
Application Instructions
| Assay Time | ~ 5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HEXA |
| Gene Full Name | hexosaminidase A (alpha polypeptide) |
| Background | This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009] |
| Function | Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity. [UniProt] |
| PTM | N-linked glycan at Asn-115 consists of Man(3)-GlcNAc(2). |
Images (1) Click the Picture to Zoom In
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ARG83298 Human HEXA ELISA Kit standard curve image
ARG83298 Human HEXA ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83298 Human HEXA ELISA Kit User manual |
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