ARG70390
Human GIF / Gastric intrinsic factor recombinant protein (His-tagged, C-ter)
Human GIF / Gastric intrinsic factor recombinant protein (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | E. coli expressed, His-tagged (C-ter) Human GIF / Gastric intrinsic factor recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | GIF / Gastric intrinsic factor |
| Species | Human |
| A.A. Sequence | Met1 - Tyr417 |
| Expression System | E. coli |
| Protein Full Name | Cobalamin binding intrinsic factor |
| Alternate Names | CBLIF; Cobalamin Binding Intrinsic Factor; IFMH; INF; IF; TCN3; GIF; Gastric Intrinsic Factor (Vitamin B Synthesis); Gastric Intrinsic Factor; Intrinsic Factor |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is <0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | >98% (by SDS-PAGE) |
| Buffer | PBS (pH 8.0) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not <200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CBLIF |
|---|---|
| Gene Full Name | Cobalamin Binding Intrinsic Factor |
| Background | This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. |
| Function | Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis. |
| Cellular Localization | Secreted |
| PTM | Disulfide bond, Glycoprotein, Phosphoprotein |
Images (1) Click the Picture to Zoom In
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ARG70390 Human GIF / Gastric intrinsic factor recombinant protein (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70390 Human GIF / Gastric intrinsic factor recombinant protein (His-tagged, C-ter)
