ARG70367
Human Eotaxin 3 recombinant protein (Active) (Tag free)
Human Eotaxin 3 recombinant protein (Active) (Tag free) for Functional study,SDS-PAGE and Human
Overview
| Product Description | E. coli expressed Active Human Eotaxin 3 recombinant protein |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms |
| Tested Application | FuncSt, SDS-PAGE |
| Target Name | Eotaxin 3 |
| Species | Human |
| A.A. Sequence | TRGSD ISKTC CFQYS HKPLP WTWVR SYEFT SNSCS QRAVI FTTKR GKKVC THPRK KWVQK YISLL KTPKQ L |
| Expression System | E. coli |
| Activity | Active |
| Activity Note | Determined by its ability to chemoattract human CCR3/HEK293 cells. The maximum activity was achieved at 2μg/ml. |
| Alternate Names | CCL26; C-C motif chemokine ligand 26; IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha; CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha (MIP-4-alpha); Small-inducible cytokine A26; SCYA26; Thymic stroma chemokine-1 |
Application Instructions
| Observed Size | 8.4 kDa |
|---|
Properties
| Form | Powder |
|---|---|
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
Bioinformation
| Gene Symbol | CCL26 |
|---|---|
| Gene Full Name | C-C motif chemokine ligand 26 |
| Background | This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020] |
| Function | Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca2+ mobilization in eosinophils. Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis [provide by uniprot] |
| Cellular Localization | Secreted |
| Calculated MW | 10.6 kDa (full-length). 8.4 kDa (mature) |
| PTM | Disulfide bond |
