ARG83228
Human Complement C2 ELISA Kit
Human Complement C2 ELISA Kit for ELISA and Human
Overview
| Product Description | ARG83228 Human Complement C2 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Complement C2 in Serum, Plasma, Urine and Cell culture supernatants. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | There is no detectable cross-reactivity with other relevant proteins. |
| Target Name | Complement C2 |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 25 pg/ml |
| Detection Range | 312 pg/ml - 20,000 pg/ml |
| Sample Type | Serum, Plasma, Urine and Cell culture supernatants |
| Precision | Intra-Assay CV: 4.7% Inter-Assay CV: 3.7% |
| Alternate Names | C2; Complement C2; Complement Component 2; C3/C5 Convertase; EC 3.4.21.43; Complement Component C2; EC 3.4.21; ARMD14; CO2 |
Application Instructions
| Assay Time | ~ 5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | C2 |
| Gene Full Name | Complement C2 |
| Background | Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined. |
| Function | Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. |
| Cellular Localization | Secreted |
| PTM | Disulfide bond, Glycoprotein |
Images (1) Click the Picture to Zoom In
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ARG83228 Human Complement C2 ELISA Kit standard curve image
ARG83228 Human Complement C2 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83228 Human Complement C2 ELISA Kit User manual |
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