ARG70522
Human CD62P / P-Selectin recombinant protein (His-tagged)
Human CD62P / P-Selectin recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Human CD62P / P-Selectin recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD62P / P-Selectin |
| A.A. Sequence | Trp42 - Ala771 |
| Expression System | CHO |
| Alternate Names | SELP; Selectin P; PADGEM; GMP140; CD62P; CD62; PSEL; GRMP; Platelet Activation Dependent Granule-External Membrane Protein; Selectin P (Granule Membrane Protein 140kDa, Antigen CD62); Leukocyte-Endothelial Cell Adhesion Molecule 3; CD62 Antigen-Like Family Member P; Granule Membrane Protein 140kDa; Granule Membrane Protein 140; P-Selectin; GMP-140; LECAM3; Selectin P (Granule Membrane Protein 140kD, Antigen CD62); Platelet Alpha-Granule Membrane Protein; Granulocyte Membrane Protein; CD62P Antigen; Antigen CD62; GMRP |
Properties
| Form | Powder |
|---|---|
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | SELP |
|---|---|
| Gene Full Name | Selectin P |
| Background | This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008] |
| Function | Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3). [Uniprot] |
