ARG70519
Human CD125 / IL5RA recombinant protein (His-tagged)
Human CD125 / IL5RA recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | CHO expressed, His-tagged Human CD125 / IL5RA recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD125 / IL5RA |
| A.A. Sequence | Met1 - Glu335 |
| Expression System | CHO |
| Alternate Names | IL5RA; Interleukin 5 Receptor Subunit Alpha; CDw125; CD125; IL5R; Interleukin-5 Receptor Subunit Alpha; Interleukin 5 Receptor, Alpha; IL-5 Receptor Subunit Alpha; IL-5R Subunit Alpha; CD125 Antigen; Interleukin-5 Receptor Alpha Chain; Interleukin 5 Receptor Type 3; IL-5R-Alph; HSIL5R3; IL-5RA |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IL5RA |
|---|---|
| Gene Full Name | Interleukin 5 Receptor Subunit Alpha |
| Background | The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011] |
| Function | In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. [Uniprot] |
