ARG70529
Human CD124 / IL4 Receptor recombinant protein (His-tagged)
Human CD124 / IL4 Receptor recombinant protein (His-tagged) for SDS-PAGE
Overview
| Product Description | HEK293 expressed, His-tagged Human CD124 / IL4 Receptor recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CD124 / IL4 Receptor |
| A.A. Sequence | Met26 - His232 |
| Expression System | HEK293 |
| Alternate Names | IL4R; Interleukin 4 Receptor; CD124; Interleukin-4 Receptor Subunit Alpha; IL-4 Receptor Subunit Alpha; Interleukin 13 Receptor; IL-4RA; IL4RA; Interleukin-4 Receptor Alpha Chain; IL-4R Subunit Alpha; CD124 Antigen; IL-4R-Alpha |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IL4R |
|---|---|
| Gene Full Name | Interleukin 4 Receptor |
| Background | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] |
| Function | Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. [Uniprot] |
