ARG70476
Human CCL3 / MIP1 alpha recombinant protein (Active) (His-Tagged, N-ter)
Human CCL3 / MIP1 alpha recombinant protein (Active) (His-Tagged, N-ter) for SDS-PAGE
Overview
| Product Description | E. coli expressed, His-Tagged (N-ter)Active Human CCL3 / MIP1 alpha recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | CCL3 / MIP1 alpha |
| Species | Human |
| A.A. Sequence | Ala27-Ala92 |
| Expression System | E. coli |
| Activity | Active |
| Activity Note | Measure by its ability to chemoattract human PBMC using a concentration range of 5 -50 ng/mL. |
| Alternate Names | CCL3; C-C Motif Chemokine Ligand 3; G0S19-1; MIP-1-Alpha; LD78ALPHA; SCYA3; Small Inducible Cytokine A3 (Homologous To Mouse Mip-1a); Macrophage Inflammatory Protein 1-Alpha; Tonsillar Lymphocyte LD78 Alpha Protein; G0/G1 Switch Regulatory Protein 19-1; C-C Motif Chemokine; PAT 464.1; SIS-Beta; MIP1A; LD78; SCI; Macrophage Inflammatory Protein 1 Alpha; Chemokine (C-C Motif) Ligand; Small-Inducible Cytokine A3; MIP-1-ALPHA |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is <0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | >95% (by SDS-PAGE) |
| Buffer | PBS (pH 8.0) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not <200 µg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CCL3 |
|---|---|
| Gene Full Name | C-C Motif Chemokine Ligand 3 |
| Background | This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1 |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). |
| Cellular Localization | Secreted |
| PTM | Disulfide bond |
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ARG70476 Human CCL3 / MIP1 alpha recombinant protein (Active) (His-Tagged, N-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70476 Human CCL3 / MIP1 alpha recombinant protein (Active) (His-Tagged, N-ter)
