ARG81336
Human Angiopoietin 2 ELISA Kit
Human Angiopoietin 2 ELISA Kit for ELISA and Human
Overview
| Product Description | ARG81336 Human Angiopoietin 2 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Angiopoietin 2 in serum and cell culture supernatant. |
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| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | Recognizes natural and recombinant Angiopoietin 2. No cross reactivity with VEGF-A, GM-CSF, IL-34, IL-29 IFNg, IL-2, IL-10, CD138, MICB, MCP-1. |
| Target Name | Angiopoietin 2 |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 25 pg/ml |
| Sample Type | Serum and cell culture supernatants. |
| Standard Range | 125 - 4000 pg/ml |
| Sample Volume | 50 µl |
| Alternate Names | ANG-2; Angiopoietin-2; ANG2; AGPT2 |
Application Instructions
| Assay Time | ~ 4 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ANGPT2 |
| Gene Full Name | angiopoietin 2 |
| Background | The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. [UniProt] |
| Highlight | Related products: Angiopoietin antibodies; Angiopoietin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
Images (1) Click the Picture to Zoom In
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ARG81336 Human Angiopoietin 2 ELISA Kit standard curve image
ARG81336 Human Angiopoietin 2 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG81336 Human Angiopoietin-2 ELISA Kit User's manual |
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