ARG43807
Anti-RGS2 antibody
Anti-RGS2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RGS2 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RGS2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to human RGS2 |
| Conjugation | Un-conjugated |
| Alternate Names | RGS2; Regulator Of G Protein Signaling 2; G0S8; Cell Growth-Inhibiting Gene 31 Protein |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | A172 | ||||||
| Observed Size | 24 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen |
| Buffer | pH 7.4 PBS, 0.05% NaN3, and 40% Glycerol |
| Concentration | 1.68 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P41220 Human Regulator of G-protein signaling 2 |
|---|---|
| Gene Symbol | RGS2 |
| Gene Full Name | Regulator Of G Protein Signaling 2 |
| Background | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009] |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, 19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320). ( RGS2_HUMAN,P41220 ) |
| Cellular Localization | Cell membrane; Cytoplasm; Membrane; Mitochondrion; Nucleus |
| Calculated MW | 24 kDa |
| PTM | Phosphoprotein |
Images (2) Click the Picture to Zoom In
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ARG43807 anti-GRS2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded human esophagus cancer tissue stained with ARG43807 anti-GRS2 antibody at 1:100 dilution (Original magnification: [X200]
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ARG43807 anti-GRS2 antibody WB image
Western blot: 40 µg of A172 cell lysates stained with ARG43807 anti-RGS2 antibody at dilution 1: 1000.
