ARG45167
Anti-C9orf72 antibody
Anti-C9orf72 antibody for Flow cytometry,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes C9orf7 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | C9orf7 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to N-terminal region of human C9orf7. |
| Conjugation | Un-conjugated |
| Alternate Names | C9ORF72; C9orf72-SMCR8 complex subunit; Guanine nucleotide exchange C9orf72; C9orf72 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 65 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | C9ORF72 |
| Gene Full Name | C9orf72-SMCR8 complex subunit |
| Background | The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016] |
| Function | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophag. [UniProt] |
| Cellular Localization | Secreted; Lysosome; Endosome; Nucleus; Cytoplasm, P-body; Cytoplasm; Cell projection, axon 1; Cell projection, growth cone; Perikaryon; dendrite; Nucleus membrane; Peripheral membrane protein. [UniProt] |
| Calculated MW | 54 kDa |
Images (4) Click the Picture to Zoom In
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ARG45167 Anti-C9orf72 antibody FACS image
Flow Cytometry: U20S stained with ARG45167 Anti-C9orf72 antibody at 1 µg/10^6 cells dilution.
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ARG45167 Anti-C9orf72 antibody WB image
Western blot: Hela, A431, and A549 stained with ARG45167 Anti-C9orf72 antibody at 0.5 μg/ml dilution.
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ARG45167 Anti-C9orf72 antibody WB image
Western blot: Rat brain, rat liver, and C6 stained with ARG45167 Anti-C9orf72 antibody at 0.5 μg/ml dilution.
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ARG45167 Anti-C9orf72 antibody WB image
Western blot: Mouse liver and HEPA1-6 stained with ARG45167 Anti-C9orf72 antibody at 0.5 μg/ml dilution.
