ACE2, receptor of SARS-CoV-2

The novel coronavirus (SARS-CoV-2) which caused an epidemic of acute respiratory syndrome shares 79.5% sequence identify to SARS-CoV. Recently, several reports indicated that SARS-CoV-2 and SARS-CoV share the same receptor ACE2 for mediating viral entry into host cells.

ACE2 (angiotensin-converting enzyme-2) is previously known as the receptor for SARS-CoV. Based on structural analysis, Wan et al., and Xu et al., point that ACE2 could be the receptor for SARS-CoV-2. Zhou et al., conducted virus infectivity studies and confirmed that ACE2 is required for entry of 2019-nCoV into HeLa cells. More understanding about the interaction of SARS-CoV-2 and ACE2 can lead to anti-infective strategies such as ACE2 protein blockade or neutralizing antibodies.

arigo offers IP-grade AEC2 antibody (ARG41099) that is excellent for studying the interaction of SARS-CoV-2 and ACE2 and the vital infection. Moreover, a series of antibodies and ELISA kit are available to facilitate coronavirus research.

ACE2 antibody & ELISA kit

ACE2 antibody (ARG41099)
Reactivity: Hu, Ms, Rat
Application: IHC-P, IP, WB

Human ACE2 ELISA Kit (ARG80959)
Sensitivity: 12.5 pg/ml
Sample: Serum, plasma, lysate, cell culture supernatant

Coronavirus antibodies & ELISA kits

SARS-CoV Spike protein antibody (ARG54885)
SARS-CoV Spike protein antibody (ARG54886)
SARS -CoV M protein antibody (ARG54884)
MERS-CoV Nucleocapsid antibody (ARG10987)
Anti-Canine Coronavirus IgG ELISA Kit (ARG80985)
Anti-Feline Coronavirus antibody ELISA Kit (ARG81004)
Bovine coronavirus surface antigen antibody [5A4] (ARG10284)
Feline Coronavirus antibody (ARG22654)

References

1. Wan et al., (2020) Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Journal of Virology. 2020 Mar 17;94(7).
2. Xu et al., (2020) Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. SCIENCE CHINA Life Sciences 63.
3. Zhou et al., (2020) Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin. doi:10.1101/2020.01.22.914952.