Cholesterol, the weakness of anaplastic large cell lymphoma (ALCL)

Anaplastic large-cell lymphoma (ALCL) is a category of non-Hodgkin lymphoma involving aberrant T cells or null lymphocytes. It is aggressive and often relapse. Scientists continue developing new therapies to treat this cancer.

In recent Nature journal, Garcia-Bermudez et al. reported that cholesterol auxotrophy is a promising strategy for the treatment of ALCL. They found that ALK+ ALCL cell lines is auxotrophic for cholesterol due to genetic defect and thus highly expressing LDLR for cholesterol uptake. The authors further demonstrated that LDLR depletion inhibited the growth of mouse tumour xenografts derived from ALK+ ALCL cancer cell lines. Their data identify cholesterol uptake through LDLR as a therapeutic target for ALK+ ALCL.

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ALCL pathological markers