ARG66201
anti-CD30 antibody [SQab1723]
anti-CD30 antibody [SQab1723] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant Rabbit Monoclonal antibody [SQab1723] recognizes CD30 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab1723 |
| Target Name | CD30 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the C-terminus of CD30. |
| Conjugation | Un-conjugated |
| Alternate Names | Tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30; Ki-1; Lymphocyte activation antigen CD30; CD antigen CD30; D1S166E; CD30L receptor |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: Heat mediation was performed using Tris/EDTA buffer (pH 9.0) * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P28908 Human Tumor necrosis factor receptor superfamily member 8 |
|---|---|
| Gene Symbol | TNFRSF8 |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 8 |
| Background | CD30 is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| Function | CD30 is a receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). [UniProt] |
| Highlight | Related products: CD30 antibodies; CD30 ELISA Kits; Related news: Cancer Pathology Markers (SQ clones) Cholesterol, the weakness of anaplastic large cell lymphoma (ALCL) |
| Calculated MW | 64 kDa |
| PTM | Phosphorylated on serine and tyrosine residues. |
Images (2) Click the Picture to Zoom In
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ARG66201 anti-CD30 antibody [SQab1723] IHC-P image
Immunohistochemistry: Formalin‐fixed and paraffin‐embedded Human tonsil tissue stained with ARG66201 anti-CD30 antibody [SQab1723] at 1:1000 dilution.
Antigen retrieval: Heat mediated was performed using Tris/EDTA buffer pH 9.0
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ARG66201 anti-CD30 antibody [SQab1723] IHC-P image
Immunohistochemistry: Formalin‐fixed and paraffin‐embedded Human hodgkin lymphoma tissue stained with ARG66201 anti-CD30 antibody [SQab1723] at 1:1000 dilution.
Antigen retrieval: Heat mediated was performed using Tris/EDTA buffer pH 9.0
