Vascular development is regulated by FGF-dependent metabolic control

It is known that VEGF is the key molecule for the development of the vascular endothelial cell lineage and for the formation of early capillary networks. PDGF-B and angiopoietin-1 is required for the maturation and remodeling of vascular networks interactions between mural cells and vascular endothelial cells.

Yu et al. reported that FGFR signaling control c-MYC expression which in turn regulates expression of the glycolytic enzyme hexokinase 2 (HK2). A decrease of HK2 levels results in decreased glycolysis and leads to impaired endothelial cell proliferation and migration, while HK2 overexpression partly rescues the defects caused by suppression of FGF signaling.

The unexpected FGF-MYC-HK2-dependent regulation of vascular development may open new therapeutic possibilities for the diseases associated with abnormal vascular growth.

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