Hypoxia-induced transcription, histone demethylases are involved

Hypoxia (oxygen deficiency) is a contributing factor in many human diseases. Previous studies focused on the role and regulation of hypoxia-inducible factor 1 (HIF-1) in hypoxia-induced gene transcription. Recently, two groups reported that certain histone demethylases also sense the oxygen deficiency and alter gene expression in a HIF-1-independent manner.

Batie et al. and Chakraborty et al. respectively demonstrated that the lysine-specific demethylases KDM5A and KDM6A act as oxygen sensors and directly alter gene expression by changing the chromatin structure.

arigo offer quality hypoxia markers and a series of antibodies against methylated H3 or demethylases to facilitate related research.

Hypoxia markers

HIF-1 alpha antibody (ARG10515)