ARG54857
anti-KDM6B / JMJD3 antibody
anti-KDM6B / JMJD3 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Gene Regulation antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KDM6B / JMJD3 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | KDM6B / JMJD3 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 1-30 (N-terminus) of Human JMJD3. |
| Conjugation | Un-conjugated |
| Alternate Names | JmjC domain-containing protein 3; Lysine-specific demethylase 6B; JMJD3; Lysine demethylase 6B; Jumonji domain-containing protein 3; EC 1.14.11.- |
Application Instructions
| Application Suggestion |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | HeLa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KDM6B |
| Gene Full Name | lysine (K)-specific demethylase 6B |
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. [UniProt] |
| Cellular Localization | Nucleus. |
| Highlight | Related products: KDM6B antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Hypoxia-induced transcription, histone demethylases are involved |
| Research Area | Gene Regulation antibody |
| Calculated MW | 177 kDa |
Images (3) Click the Picture to Zoom In
-
ARG54857 anti-KDM6B / JMJD3 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG54857 anti-KDM6B / JMJD3 antibody (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI (blue) for nuclear staining.
-
ARG54857 anti-KDM6B / JMJD3 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human brain tissue stained with ARG54857 anti-KDM6B / JMJD3 antibody.
-
ARG54857 anti-KDM6B / JMJD3 antibody WB image
Western blot: HeLa cell lysate stained with ARG54857 anti-KDM6B / JMJD3 antibody.
