Ripoptosome & Necrosome antibody panels are launched
Ripoptosome & Necrosome antibody panels are launched
Necroptosis and apoptosis are parallel cell death pathways in response to extrinsic death signals. The activation of death receptors induces the formation of ripoptosome which is a platform to switch non-inflammatory cell death apoptosis and inflammatory cell death necroptosis. The ripoptosome components includes RIP1, Caspase-8, and FADD. In ripoptosome, Caspase-8 activation leads to apoptosis, whereas Caspase-8 inhibition triggers necrosome assembly in which RIP1 and RIP3 are activated by phosphorylation and the recruited MLKL is subsequently phosphorylated by RIP3, resulting in MLKL oligomerization and insertion into the plasma membrane, consequently executing necroptosis.
Necroptosis is associated with in a variety of pathophysiological processes, including cancer, liver diseases, kidney injury, cardiovascular diseases, neurodegenerative diseases, and allergic inflammation. A better understanding about the regulation of ripoptosome and necrosome opens new therapeutic avenues for treating necroptosis‑related diseases. arigo offers ripoptosome and necrosome antibody panels to facilitate necroptosis/apoptosis research.
● Mouse Ripoptosome Antibody Panel (ARG30350)
Ideal to distinguish extrinsic apoptosis, RIP1-dependent apoptosis, and necroptosis
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- Includes ripoptosome components RIP1 and Caspase-8 antibodies |
| Component | Reactivity | Application | Pkg |
| Caspase-8 antibody | Hu, Ms, Rat | IHC-P, WB | 20 μl |
| RIP1 antibody [SQab22276] | Ms | IHC-P, WB | 20 μl |
| RIP1 phospho (Ser166) antibody [YJY-1-5] | Hu, Ms, Rat | ICC/IF, IHC-Fr, IHC-P, IP, WB | 20 μl |
| RIP3 phospho (Ser232) antibody | Ms | WB | 20 μl |
● Necrosome Antibody Panel (ARG30344)
Ideal to detect the necrosome and necroptosis
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- Includes necrosome components RIP1, RIP3, and MLKL antibodies |
| Component | Reactivity | Application | Pkg |
| RIP1 antibody | Hu, Ms, Rat | ICC/IF, WB | 20 μg |
| RIP3 antibody | Hu, Ms, Rat | ELISA, ICC/IF, IHC-Fr, IHC-P, IP, WB | 20 μg |
| MLKL antibody | Hu, Ms | IHC-P, WB | 20 μl |
