ARG45132
anti-TNFSF18 / GITRL antibody
anti-TNFSF18 / GITRL antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TNFSF18 / GITRL |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TNFSF18 / GITRL |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human TNFSF18. |
| Conjugation | Un-conjugated |
| Alternate Names | TNFSF18; TNF superfamily member 18; Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; TNFSF18; AITRL; GITRL; TL6; UNQ149/PRO175; _x000D_ Tumor Necrosis Factor Ligand 2A; AITR Ligand; GITR Ligand; TNLG2A |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 15 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9UNG2 Human Tumor necrosis factor ligand superfamily member 18 |
|---|---|
| Gene Symbol | TNFSF18 |
| Gene Full Name | TNF superfamily member 18 |
| Background | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008] |
| Function | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. [UniProt] |
| Cellular Localization | Cell membrane. [UniProt] |
| Calculated MW | 20 kDa |
| PTM | Disulfide bond; Glycoprotein. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG45132 anti-TNFSF18 / GITRL antibody IHC-P image
Immunohistochemistry: Human lung cancer stained with ARG45132 anti-TNFSF18 / GITRL antibody at 1 μg/ml dilution.
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ARG45132 anti-TNFSF18 / GITRL antibody WB image
Western blot: TNFSF18 recombinant protein stained with ARG45132 anti-TNFSF18 / GITRL antibody at 0.5 μg/ml dilution.
