ARG10796
anti-PDE3A antibody
anti-PDE3A antibody for Confocal microscopy (Confocal),Dot blot,ELISA,Fluorescence Resonance Energy Transfer,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat,Monkey,Xenopus
Publication1
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PDE3A |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Mk, Xenopus |
| Tested Application | Confocal, Dot, ELISA, FRET, ICC/IF, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PDE3A |
| Antigen Species | Human |
| Immunogen | Synthetic peptide selective only for PDE3A variants. |
| Conjugation | Un-conjugated |
| Alternate Names | EC 3.1.4.17; Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB; cGMP-inhibited 3',5'-cyclic phosphodiesterase A |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 30% Glycerol and 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
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| Gene Symbol | PDE3A |
| Gene Full Name | phosphodiesterase 3A, cGMP-inhibited |
| Background | This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. [UniProt] |
| Calculated MW | 125 kDa |
Images (2) Click the Picture to Zoom In
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ARG10796 anti-PDE3A antibody ICC/IF image
Immunofluorescence: Ice-cold Acetone/Methanol (1:1) fixed (5 min) cultured rat smooth muscle cells stained with ARG10796 anti-PDE3A antibody (red) at 1:100 dilution. Nuclei were counterstained with DAPI (blue).
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ARG10796 anti-PDE3A antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human ovarian medulla tissue stained with ARG10796 anti-PDE3A antibody at 1:100 dilution.
Specific References
Electroacupuncture promotes the gastrointestinal motility of diabetic mice by CNP/NPR-B-cGMP and PDE3A-cGMP signaling.
WB / Mouse
