ARG44379
anti-PCCA antibody
anti-PCCA antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PCCA |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PCCA |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 449-728 of human PCCA |
| Conjugation | Un-conjugated |
| Alternate Names | PCCA; Propionyl-CoA Carboxylase Subunit Alpha; Propionyl-CoA Carboxylase Alpha Chain, Mitochondrial; Propionyl Coenzyme A Carboxylase, Alpha Polypeptide; EC 6.4.1.3; Propanoyl-CoA:Carbon Dioxide Ligase Alpha Subunit; Propanoyl-CoA:Carbon Dioxide Ligase Subunit Alpha; Propionyl CoA Carboxylase, Alpha Polypeptide; Propionyl-CoA Carboxylase Alpha Subunit; PccA Complementation Group; PCCase Alpha Subunit; PCCase Subunit Alpha |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.01% Thimerosal and 50% Glycerol. |
| Preservative | 0.01% Thimerosal |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PCCA |
| Gene Full Name | Propionyl-CoA Carboxylase Subunit Alpha |
| Background | The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Function | This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites |
| Cellular Localization | Mitochondrion |
| Calculated MW | 80 kDa |
| PTM | Acetylation,Phosphoprotein |
Images (5) Click the Picture to Zoom In
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ARG44379 anti-PCCA antibody IHC-P image
Immunohistochemistry: Human liver stained with ARG44379 anti-PCCA antibody at 1:100 dilution.
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ARG44379 anti-PCCA antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG44379 anti-PCCA antibody at 1:100 dilution.
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ARG44379 anti-PCCA antibody WB image
Western blot: Rat kidney stained with ARG44379 anti-PCCA antibody at 1:3000 dilution.
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ARG44379 anti-PCCA antibody IHC-P image
Immunohistochemistry: Mouse kidney stained with ARG44379 anti-PCCA antibody at 1:100 dilution.
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ARG44379 anti-PCCA antibody WB image
Western blot: Mouse liver, Mouse brain and Mouse kidney stained with ARG44379 anti-PCCA antibody at 1:3000 dilution.
