ARG43078
anti-Nogo Receptor antibody
anti-Nogo Receptor antibody for Immunoprecipitation,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Nogo Receptor |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Nogo Receptor |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human Nogo Receptor. |
| Conjugation | Un-conjugated |
| Alternate Names | Nogo-66 receptor; NGR; Reticulon-4 receptor; Nogo receptor; NOGOR; NgR |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HepG2 |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RTN4R |
| Gene Full Name | reticulon 4 receptor |
| Background | This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008] |
| Function | Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). [UniProt] |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. [UniProt] |
| Calculated MW | 51 kDa |
| PTM | N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG43078 anti-Nogo Receptor antibody WB image
Western blot: HepG2 cell lysate stained with ARG43078 anti-Nogo Receptor antibody.
