ARG42440
anti-NR2F6 antibody [EM-51]
anti-NR2F6 antibody [EM-51] for Flow cytometry,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [EM-51] recognizes NR2F6 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, WB |
| Specificity | The mouse monoclonal antibody EM-51 recognizes NR2F6, a transcriptional repressor (intracellular antigen) expressed mainly in the heart, placenta, liver, skeletal muscle, kidney and pancreas, but also e.g. in T cell subpopulations. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | EM-51 |
| Isotype | IgG2a, kappa |
| Target Name | NR2F6 |
| Antigen Species | Human |
| Immunogen | Recombinant Human NR2F6 protein (expressed in E. coli). |
| Conjugation | Un-conjugated |
| Alternate Names | EAR-2; V-erbA-related protein 2; Nuclear receptor subfamily 2 group F member 6; ERBAL2; EAR2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS and 15 mM Sodium azide. |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P10588 Human Nuclear receptor subfamily 2 group F member 6 |
|---|---|
| Gene Symbol | NR2F6 |
| Gene Full Name | nuclear receptor subfamily 2, group F, member 6 |
| Function | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 43 kDa |
