ARG40434
anti-MTAP antibody
anti-MTAP antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MTAP |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MTAP |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-283 of Human MTAP (NP_002442.2). |
| Conjugation | Un-conjugated |
| Alternate Names | 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MSAP; LGMBF; EC 2.4.2.28; HEL-249; DMSFH; BDMF; S-methyl-5'-thioadenosine phosphorylase; MTAPase; MTAP; DMSMFH; c86fus |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | 293T | ||||||||
| Observed Size | 31 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q13126 Human S-methyl-5'-thioadenosine phosphorylase Swiss-port # Q9CQ65 Mouse S-methyl-5'-thioadenosine phosphorylase |
|---|---|
| Gene Symbol | MTAP |
| Gene Full Name | methylthioadenosine phosphorylase |
| Background | This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008] |
| Function | Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. [UniProt] |
| Cellular Localization | Cytoplasm. Nucleus. [UniProt] |
| Calculated MW | 31 kDa |
Images (3) Click the Picture to Zoom In
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ARG40434 anti-MTAP antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG40434 anti-MTAP antibody.
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ARG40434 anti-MTAP antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse liver stained with ARG40434 anti-MTAP antibody at 1:100 dilution.
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ARG40434 anti-MTAP antibody WB image
Western blot: 25 µg of 293T cell lysate stained with ARG40434 anti-MTAP antibody at 1:1000 dilution.
