ARG11165
anti-LIAS antibody
anti-LIAS antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes LIAS. |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | LIAS |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human LIAS. |
| Conjugation | Un-conjugated |
| Alternate Names | LIAS; Lipoic Acid Synthetase; LAS; Lipoyl Synthase, Mitochondrial; Lipoate Synthase; Lipoic Acid Synthase |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | LIAS |
| Gene Full Name | Lipoic Acid Synthetase |
| Background | The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. Localized in the mitochondrion, this iron-sulfur enzyme catalyzes the final step in the de novo pathway for the biosynthesis of lipoic acid, a potent antioxidant. The deficient expression of this enzyme has been linked to conditions such as diabetes, atherosclerosis and neonatal-onset epilepsy. Alternative splicing occurs at this locus, and several transcript variants encoding distinct isoforms have been identified. |
| Function | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. |
| Cellular Localization | Mitochondrion |
| Calculated MW | 42 kDa |
Images (2) Click the Picture to Zoom In
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ARG11165 anti-LIAS antibody WB image
Western blot: A549 stained with ARG11165 anti-LIAS antibody at 1:2500 dilution.
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ARG11165 anti-LIAS antibody WB image
Western blot: Mouse Liver stained with ARG11165 anti-LIAS antibody at 1:2500 dilution.
