ARG53982
anti-KDM5C / Jarid 1C / SMCX antibody
anti-KDM5C / Jarid 1C / SMCX antibody for ICC/IF,Western blot and Human
Gene Regulation antibody
Overview
| Product Description | Mouse Monoclonal antibody recognizes KDM5C / Jarid 1C / SMCX |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | KDM5C / Jarid 1C / SMCX |
| Antigen Species | Human |
| Immunogen | Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli |
| Conjugation | Un-conjugated |
| Alternate Names | XE169; SMCX; DXS1272E; JARID1C; Jumonji/ARID domain-containing protein 1C; Protein Xe169; Histone demethylase JARID1C; EC 1.14.11.-; MRX13; MRXJ; Lysine-specific demethylase 5C; MRXSJ; Protein SmcX; MRXSCJ |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 220 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.1M Tris-Glycine (pH 7.4), 150 mM NaCl, 0.2% Sodium azide and 50% Glycerol |
| Preservative | 0.2% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KDM5C |
| Gene Full Name | lysine (K)-specific demethylase 5C |
| Background | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. |
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). [UniProt] |
| Cellular Localization | Nucleus |
| Research Area | Gene Regulation antibody |
| Calculated MW | 176 kDa |
Images (2) Click the Picture to Zoom In
-
ARG53982 anti-KDM5C / Jarid 1C / SMCX antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG53982 anti-KDM5C / Jarid 1C / SMCX antibody at 1:150 dilution.
-
ARG53982 anti-KDM5C / Jarid 1C / SMCX antibody WB image
Western blot: MCF7 cell lysate stained with ARG53982 anti-KDM5C / Jarid 1C / SMCX antibody at 1:500 dilution.
