ARG43868
anti-IL17 / IL17A antibody [9F9] (APC)
anti-IL17 / IL17A antibody [9F9] (APC) for Flow cytometry and Human
Overview
| Product Description | APC-conjugated Mouse Monoclonal antibody recognize IL17 / IL17A. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 9F9 |
| Isotype | IgG1 kappa |
| Target Name | IL17 / IL17A |
| Antigen Species | Human |
| Immunogen | Human IL7 / IL17A fusion protein. |
| Conjugation | APC |
| Protein Full Name | Interleukin-17A |
| Alternate Names | L17A; Interleukin 17A; IL-17A; IL-17; CTLA8; IL17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Cytotoxic T-Lymphocyte-Associated Protein 8; Cytotoxic T-Lymphocyte-Associated Antigen 8; Interleukin-17A; CTLA-8; Interleukin-17; ILA17 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Do not freeze. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL17A |
| Gene Full Name | Interleukin 17A |
| Background | This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020] |
| Function | Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. |
| Cellular Localization | Secreted |
| Calculated MW | 18 kDa |
| PTM | Disulfide bond; Glycoprotein |
Images (1) Click the Picture to Zoom In
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ARG43868 anti-IL17 / IL17A antibody [9F9] (APC) FACS image
Flow Cytometry: Human whole blood stained with ARG43868 anti-IL17 / IL17A antibody [9F9] (APC) at 1:10 dilution.
