ARG55426
anti-IGF2BP2 antibody
anti-IGF2BP2 antibody for Flow cytometry,Western blot and Human
Gene Regulation antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes IGF2BP2 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | IGF2BP2 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 530-556 (C-terminus) of Human IGF2BP2. |
| Conjugation | Un-conjugated |
| Alternate Names | IMP2; VICKZ2; Hepatocellular carcinoma autoantigen p62; IMP-2; VICKZ family member 2; IGF2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2; Insulin-like growth factor 2 mRNA-binding protein 2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HepG2 |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Y6M1 Human Insulin-like growth factor 2 mRNA-binding protein 2 |
|---|---|
| Gene Symbol | IGF2BP2 |
| Gene Full Name | insulin-like growth factor 2 mRNA binding protein 2 |
| Background | This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014] |
| Function | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules |
| Research Area | Gene Regulation antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody |
| Calculated MW | 66 kDa |
Images (2) Click the Picture to Zoom In
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ARG55426 anti-IGF2BP2 antibody WB image
Western blot: 35 µg of HepG2 cell lysate stained with ARG55426 anti-IGF2BP2 antibody.
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ARG55426 anti-IGF2BP2 antibody FACS image
Flow Cytometry: HepG2 cells stained with ARG55426 anti-IGF2BP2 antibody (right histogram) or without primary antibody control (left histogram), followed by incubation with FITC labelled secondary antibody.
