ARG41439

anti-Ferritin Heavy Chain antibody

anti-Ferritin Heavy Chain antibody for ICC/IF,Western blot and Human,Mouse,Rat

publication_link Publication1

Overview

Product Description Rabbit Polyclonal antibody recognizes Ferritin Heavy Chain
Tested Reactivity Hu, Ms, Rat
Tested Application ICC/IF, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Ferritin Heavy Chain
Antigen Species Human
Immunogen Synthetic peptide of Human Ferritin.
Conjugation Un-conjugated
Alternate Names Cell proliferation-inducing gene 15 protein; HFE5; FHC; PIG15; PLIF; Ferritin H subunit; FTH; Ferritin heavy chain; EC 1.16.3.1; FTHL6

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:50 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Jurkat
Observed Size ~ 20 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 14319 Mouse FTH1

GeneID: 2495 Human FTH1

GeneID: 25319 Rat FTH1

Gene Symbol FTH1
Gene Full Name ferritin, heavy polypeptide 1
Background This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Function Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). [UniProt]
Calculated MW 21 kDa

Images (2) Click the Picture to Zoom In

  • ARG41439 anti-Ferritin antibody ICC/IF image

    Immunofluorescence: Jurkat cells stained with ARG41439 anti-Ferritin antibody.

  • ARG41439 anti-Ferritin antibody WB image

    Western blot: Jurkat cell lysate stained with ARG41439 anti-Ferritin antibody.

Specific References

Inhibition of circRNA NGFR promotes ferroptosis in gallbladder carcinoma cells

WB / Human

Desen Fan et al.
Heliyon.,  (2024)

publication_link

 

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