ARG45065
anti-EB1 / EB2 / EB3 antibody [KT65]
anti-EB1 / EB2 / EB3 antibody [KT65] for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rat Monoclonal antibody [KT65] recognizes EB1 / EB2 / EB3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | KT65 |
| Isotype | IgG2a |
| Target Name | EB1 / EB2 / EB3 |
| Antigen Species | Mouse |
| Immunogen | [KT65] was generated from a GST fusion protein containing amino acids from the C-terminal region mouse EB1. This sequence is highly conserved in human and rat EB1. |
| Conjugation | Un-conjugated |
| Alternate Names | MAPRE1; Microtubule Associated Protein RP/EB Family Member 1; EB1; Microtubule-Associated Protein RP/EB Family Member 1; Adenomatous Polyposis Coli-Binding Protein EB1; APC-Binding Protein EB1; End-Binding Protein 1 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G Purified. |
| Buffer | PBS, 0.05% NaN3 |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MAPRE1/2/3 |
| Gene Full Name | Microtubule Associated Protein RP/EB Family Member 1 |
| Background | The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008] |
| Function | Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation. May play a role in cell migration. [Uniprot] |
| Cellular Localization | Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule. [Uniprot] |
| Calculated MW | 30 kDa |
| PTM | Acetylation, Phosphoprotein. [Uniprot] |
