ARG43801
anti-DMP1 antibody
anti-DMP1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
Developmental Biology antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DMP1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DMP1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to N-terminal of Human DMP1. |
| Conjugation | Un-conjugated |
| Protein Full Name | Dolichol-phosphate mannosyltransferase subunit 1 |
| Alternate Names | DMP-1; Dentin matrix protein 1; ARHP; Dentin matrix acidic phosphoprotein 1; ARHR |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HeLa; Mouse Kidney; Rat liver | ||||||
| Observed Size | 30 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | PBS with 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DMP1 |
| Gene Full Name | dentin matrix acidic phosphoprotein 1 |
| Background | Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| Research Area | Developmental Biology antibody; Signaling Transduction antibody |
| Calculated MW | 30 kDa |
| PTM | Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif. |
Images (4) Click the Picture to Zoom In
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ARG43801 anti-DMP1 antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG43801 anti-DMP1 antibody at 1:100 dilution.
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ARG43801 anti-DMP1 antibody WB image
Western Blot: HeLa cell lysate stained with ARG43801 anti-DMP1 antibody at 1:1000 dilution.
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ARG43801 anti-DMP1 antibody WB image
Western Blot: Rat liver tissue lysate stained with ARG43801 anti-DMP1 antibody at 1:1000 dilution.
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ARG43801 anti-DMP1 antibody WB image
Western Blot: Mouse kidneytissue lysate stained with ARG43801 anti-DMP1 antibody at 1:1000 dilution.
