anti-Cytokeratin 17 antibody [SQab19157]

anti-Cytokeratin 17 antibody [SQab19157] for IHC-Formalin-fixed paraffin-embedded sections and Human


Product Description Recombinant Rabbit Monoclonal antibody [SQab19157] recognizes Cytokeratin 17
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Monoclonal
Clone SQab19157
Isotype IgG
Target Name Cytokeratin 17
Antigen Species Human
Immunogen Synthetic peptide within aa. 400-500 of Human Cytokeratin 17.
Conjugation Un-conjugated
Alternate Names CK-17; K17; PC2; Keratin, type I cytoskeletal 17; PC; Cytokeratin-17; Keratin-17; PCHC1; 39.1

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:200
Application Note IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


Form Liquid
Purification Purification with Protein A.
Buffer PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.
Preservative 0.01% Sodium azide
Stabilizer 40% Glycerol and 0.05% BSA
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 3872 Human KRT17

Swiss-port # Q04695 Human Keratin, type I cytoskeletal 17

Gene Symbol KRT17
Gene Full Name keratin 17, type I
Background This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
Function Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. [UniProt]
Cellular Localization Cytoplasm. [UniProt]
Calculated MW 48 kDa
PTM Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. [UniProt]

Images (2) Click the Picture to Zoom In

  • ARG66672 anti-Cytokeratin 17 antibody [SQab19157] IHC-P image

    Immunohistochemistry: Paraffin-embedded Human lung carcinoma tissue stained with ARG66672 anti-Cytokeratin 17 antibody [SQab19157].

  • ARG66672 anti-Cytokeratin 17 antibody [SQab19157] IHC-P image

    Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded Human esophageal carcinoma tissue stained with ARG66672 anti-Cytokeratin 17 antibody [SQab19157]. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0).