ARG58081

anti-Claudin 11 antibody

anti-Claudin 11 antibody for Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes Claudin 11
Tested Reactivity Hu, Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Claudin 11
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 26-207 of Human Claudin 11 (NP_005593.2).
Conjugation Un-conjugated
Alternate Names Oligodendrocyte-specific protein; OSP; OTM; Claudin-11

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 18417 Mouse CLDN11

GeneID: 5010 Human CLDN11

Swiss-port # O75508 Human Claudin-11

Swiss-port # Q60771 Mouse Claudin-11

Gene Symbol CLDN11
Gene Full Name claudin 11
Background This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. [UniProt]
Cellular Localization Cell junction, tight junction, Cell membrane, Multi-pass membrane protein. [UniProt]
Calculated MW 22 kDa